InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adra1b

Summary

InnateDB Protein

IDBP-621102.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adra1b

Protein Name

adrenergic receptor, alpha 1b

Synonyms

[a]1b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000129200

InnateDB Gene

IDBG-164464 (Adra1b)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004937	alpha1-adrenergic receptor activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001974	blood vessel remodeling
GO:0001975	response to amphetamine
GO:0001987	vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure
GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine
GO:0001997	positive regulation of the force of heart contraction by epinephrine-norepinephrine
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007512	adult heart development
GO:0007626	locomotory behavior
GO:0008542	visual learning
GO:0016049	cell growth
GO:0019229	regulation of vasoconstriction
GO:0035024	negative regulation of Rho protein signal transduction
GO:0035265	organ growth
GO:0042593	glucose homeostasis
GO:0043278	response to morphine
GO:0043410	positive regulation of MAPK cascade
GO:0045818	negative regulation of glycogen catabolic process
GO:0045819	positive regulation of glycogen catabolic process
GO:0048148	behavioral response to cocaine
GO:0055117	regulation of cardiac muscle contraction
GO:0071875	adrenergic receptor signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane

Protein Structure and Domains

PDB ID

MGI:104774

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001115 Alpha 1B adrenoceptor
IPR002233 Adrenoceptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00237
PR00556
PR01103

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite