InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il12b

Summary

InnateDB Protein

IDBP-621106.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il12b

Protein Name

interleukin 12b

Synonyms

Il-12b; Il-12p40; Il12p40; p40;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000125867

InnateDB Gene

IDBG-164545 (Il12b)

Protein Structure

UniProt Annotation

Function

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine- activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. {ECO:0000250}.Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak- Stat signaling cascade, stimulates memory rather than naive T- cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. {ECO:0000269PubMed:11114383}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	9 [view]
Protein-DNA	20 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004896	cytokine receptor activity
GO:0005125	cytokine activity
GO:0005126	cytokine receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0042164	interleukin-12 alpha subunit binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0045519	interleukin-23 receptor binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0002230	positive regulation of defense response to virus by host
GO:0002323	natural killer cell activation involved in immune response
GO:0002827	positive regulation of T-helper 1 type immune response
GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0002862	negative regulation of inflammatory response to antigenic stimulus
GO:0007050	cell cycle arrest
GO:0007166	cell surface receptor signaling pathway
GO:0010224	response to UV-B
GO:0010535	positive regulation of activation of JAK2 kinase activity
GO:0016477	cell migration
GO:0019221	cytokine-mediated signaling pathway
GO:0019233	sensory perception of pain
GO:0030101	natural killer cell activation
GO:0032693	negative regulation of interleukin-10 production
GO:0032700	negative regulation of interleukin-17 production
GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729	positive regulation of interferon-gamma production
GO:0032733	positive regulation of interleukin-10 production
GO:0032735	positive regulation of interleukin-12 production
GO:0032740	positive regulation of interleukin-17 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0032816	positive regulation of natural killer cell activation
GO:0032819	positive regulation of natural killer cell proliferation
GO:0032946	positive regulation of mononuclear cell proliferation
GO:0034393	positive regulation of smooth muscle cell apoptotic process
GO:0042093	T-helper cell differentiation
GO:0042102	positive regulation of T cell proliferation
GO:0042104	positive regulation of activated T cell proliferation
GO:0042510	regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042520	positive regulation of tyrosine phosphorylation of Stat4 protein
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042832	defense response to protozoan
GO:0044130	negative regulation of growth of symbiont in host
GO:0045087	innate immune response (InnateDB)
GO:0045672	positive regulation of osteoclast differentiation
GO:0045785	positive regulation of cell adhesion
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0050671	positive regulation of lymphocyte proliferation
GO:0050829	defense response to Gram-negative bacterium
GO:0051135	positive regulation of NK T cell activation
GO:0051142	positive regulation of NK T cell proliferation
GO:0051607	defense response to virus
GO:0071222	cellular response to lipopolysaccharide
GO:0071346	cellular response to interferon-gamma

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0043514	interleukin-12 complex
GO:0070743	interleukin-23 complex

Protein Structure and Domains

PDB ID

MGI:96540

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR015528 Interleukin-12 beta
IPR019482 Interleukin-12 beta, central domain

PFAM

PF00041
PF01108
PF10420

PRINTS

PR01928

PIRSF

PIRSF038007

SMART

SM00408
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References