InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lamtor3

Summary

InnateDB Protein

IDBP-621111.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lamtor3

Protein Name

late endosomal/lysosomal adaptor, MAPK and MTOR activator 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000130811

InnateDB Gene

IDBG-605437 (Lamtor3)

Protein Structure

UniProt Annotation

Function

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. {ECO:0000269PubMed:15263099, ECO:0000269PubMed:9733512}.

Subcellular Localization

Late endosome membrane {ECO:0000269PubMed:15263099, ECO:0000269PubMed:19177150}; Peripheral membrane protein {ECO:0000269PubMed:15263099, ECO:0000269PubMed:19177150}; Cytoplasmic side {ECO:0000269PubMed:15263099, ECO:0000269PubMed:19177150}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0032947	protein complex scaffold

Biological Process

GO:0032006	regulation of TOR signaling
GO:0032008	positive regulation of TOR signaling
GO:0034613	cellular protein localization
GO:0043087	regulation of GTPase activity
GO:0071230	cellular response to amino acid stimulus