InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Acot1

Summary

InnateDB Protein

IDBP-621130.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acot1

Protein Name

acyl-CoA thioesterase 1

Synonyms

ACH2; CTE-1; CTE-I; Cte1; D12Ucla1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000126448

InnateDB Gene

IDBG-156004 (Acot1)

Protein Structure

UniProt Annotation

Function

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. True acyl-CoA thioesterase being highly specific for saturated C12-C20 acyl-CoAs, with only a very low activity with decanoyl-CoA as substrate. Most active on myristoyl- and palmitoyl-CoA. Introduction of one or two double bonds decreases the activity to about half. No detectable activity with bile acid CoAs such as choloyl-CoA and chenodeoxycholoyl-CoA. {ECO:0000269PubMed:10567408}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Expressed in heart, kidney, brown adipose tissue, white adipose tissue, adrenal gland and muscle. {ECO:0000269PubMed:10567408, ECO:0000269PubMed:11330065}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016290	palmitoyl-CoA hydrolase activity
GO:0016787	hydrolase activity
GO:0016790	thiolester hydrolase activity
GO:0047617	acyl-CoA hydrolase activity

Biological Process

GO:0001676	long-chain fatty acid metabolic process
GO:0006637	acyl-CoA metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

MGI:1349396

InterPro

IPR002925 Dienelactone hydrolase
IPR006862 Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
IPR014940 BAAT/Acyl-CoA thioester hydrolase C-terminal
IPR016662 Acyl-CoA thioesterase, long chain
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF01738
PF04775
PF08840

PRINTS

PIRSF

PIRSF016521

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O55137