InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gba

Summary

InnateDB Protein

IDBP-621152.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gba

Protein Name

glucosidase, beta, acid

Synonyms

betaGC; GBA1; GC; GCase; GLUC;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000130660

InnateDB Gene

IDBG-163120 (Gba)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Lysosome membrane; Peripheral membrane protein. Note=Targeting to lysosomes occurs through an alternative MPR-independent mechanism via SCARB2. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004348	glucosylceramidase activity
GO:0005102	receptor binding
GO:0005515	protein binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006665	sphingolipid metabolic process
GO:0006680	glucosylceramide catabolic process
GO:0009268	response to pH
GO:0023021	termination of signal transduction
GO:0032715	negative regulation of interleukin-6 production
GO:0033561	regulation of water loss via skin
GO:0033574	response to testosterone
GO:0035307	positive regulation of protein dephosphorylation
GO:0043407	negative regulation of MAP kinase activity
GO:0043589	skin morphogenesis
GO:0043627	response to estrogen
GO:0046512	sphingosine biosynthetic process
GO:0046513	ceramide biosynthetic process
GO:0051384	response to glucocorticoid
GO:0071356	cellular response to tumor necrosis factor
GO:0097066	response to thyroid hormone

Cellular Component

GO:0005765	lysosomal membrane
GO:0043202	lysosomal lumen
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:95665

InterPro

IPR001139 Glycoside hydrolase, family 30
IPR017853 Glycoside hydrolase, superfamily

PFAM

PF02055

PRINTS

PR00843

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P17439

PhosphoSite

PhosphoSite-P17439

TrEMBL

UniProt Splice Variant

Entrez Gene

14466

UniGene

RefSeq

NP_032120

MGI ID

MGI Symbol

Gba

OMIM

CCDS

CCDS17493

HPRD

IMGT

EMBL

AK082767 AY115108 BC006663 M24119 M89949

GenPept

AAA37665 AAA37671 AAH06663 AAM66757 BAC38609