InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SEMA4C

Summary

InnateDB Protein

IDBP-62126.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEMA4C

Protein Name

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000306844

InnateDB Gene

IDBG-62124 (SEMA4C)

Protein Structure

UniProt Annotation

Function

Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade. {ECO:0000250, ECO:0000269PubMed:17498836}.

Subcellular Localization

Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

GO:0001843	neural tube closure
GO:0007275	multicellular organismal development
GO:0021535	cell migration in hindbrain
GO:0021549	cerebellum development
GO:0032874	positive regulation of stress-activated MAPK cascade
GO:0042692	muscle cell differentiation
GO:0071526	semaphorin-plexin signaling pathway

Cellular Component

GO:0005615	extracellular space
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030672	synaptic vesicle membrane
GO:0045211	postsynaptic membrane