Version 5.4
Mus musculus Protein: Shc2
Summary
InnateDB Protein IDBP-621265.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Shc2
Protein Name SHC (Src homology 2 domain containing) transforming protein 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000129491
InnateDB Gene IDBG-170305 (Shc2)
Protein Structure
UniProt Annotation
Function Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0035556 intracellular signal transduction
Cellular Component
Protein Structure and Domains
PDB ID MGI:106180
InterPro IPR000980 SH2 domain
IPR006019 Phosphotyrosine interaction domain, Shc-like
IPR006020 PTB/PI domain
PFAM PF00017
PF14633
PF00640
PF14719
PRINTS PR00401
PR00629
PIRSF
SMART SM00252
SM00462
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BMC3
PhosphoSite PhosphoSite-Q8BMC3
TrEMBL E9QLZ0
UniProt Splice Variant
Entrez Gene 216148
UniGene Mm.39424
RefSeq NP_001019710
MGI ID
MGI Symbol Shc2
OMIM
CCDS CCDS48620
HPRD
IMGT
EMBL AC132265 AK032878
GenPept BAC28066

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca