InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Jdp2

Summary

InnateDB Protein

IDBP-621273.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Jdp2

Protein Name

Jun dimerization protein 2

Synonyms

Jundm2; Jundp2; TIF;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000129985

InnateDB Gene

IDBG-158566 (Jdp2)

Protein Structure

UniProt Annotation

Function

Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1, such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitously expressed in all adult tissues tested as well in embryos. {ECO:0000269PubMed:11231009}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	17 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0031065	positive regulation of histone deacetylation
GO:0045599	negative regulation of fat cell differentiation