InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rasgrp3

Summary

InnateDB Protein

IDBP-621286.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rasgrp3

Protein Name

RAS, guanyl releasing protein 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000129393

InnateDB Gene

IDBG-198444 (Rasgrp3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005088	Ras guanyl-nucleotide exchange factor activity
GO:0005509	calcium ion binding
GO:0017016	Ras GTPase binding
GO:0019900	kinase binding
GO:0046582	Rap GTPase activator activity

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0007265	Ras protein signal transduction
GO:0032854	positive regulation of Rap GTPase activity
GO:0035556	intracellular signal transduction
GO:0043087	regulation of GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0032045	guanyl-nucleotide exchange factor complex
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:3028579

InterPro

IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001895 Guanine-nucleotide dissociation stimulator CDC25
IPR002048 EF-hand domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR020454 Diacylglycerol/phorbol-ester binding
IPR023578 Ras guanine nucleotide exchange factor, domain

PFAM

PF00618
PF00617
PF00036
PF13202
PF13405
PF00130

PRINTS

PR00008

PIRSF

SMART

SM00229
SM00147
SM00054
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt