InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dpp8

Summary

InnateDB Protein

IDBP-621325.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dpp8

Protein Name

dipeptidylpeptidase 8

Synonyms

2310004I03Rik; 4932434F09Rik; AI666706; DPP VIII;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000126065

InnateDB Gene

IDBG-177048 (Dpp8)

Protein Structure

UniProt Annotation

Function

Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. May play a role in T-cell activation and immune function (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0004177	aminopeptidase activity
GO:0008236	serine-type peptidase activity

Biological Process

GO:0006508

proteolysis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1921638

InterPro

IPR000383 X-Pro dipeptidyl-peptidase-like domain
IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain
IPR002469 Peptidase S9B, dipeptidylpeptidase IV N-terminal
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF02129
PF00326
PF00930

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q80YA7

PhosphoSite