InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plce1

Summary

InnateDB Protein

IDBP-621354.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plce1

Protein Name

phospholipase C, epsilon 1

Synonyms

4933403A21Rik; mKIAA1516; Plce; PLCepsilon;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000130604

InnateDB Gene

IDBG-163053 (Plce1)

Protein Structure

UniProt Annotation

Function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine- exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. {ECO:0000269PubMed:12721365, ECO:0000269PubMed:15604236, ECO:0000269PubMed:15743817, ECO:0000269PubMed:16293787}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}. Note=Recruited to plasma membrane by activated HRAS and RAP2. Recruited to perinuclear membrane by activated RAP1A. Associates with Golgi membranes (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in neurons and to a lower extent in skin, skeletal muscle and heart (at protein level). Expressed in the epidermis. {ECO:0000269PubMed:15604236, ECO:0000269PubMed:15743817}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004629	phospholipase C activity
GO:0004871	signal transducer activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity
GO:0019899	enzyme binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0006629	lipid metabolic process
GO:0007165	signal transduction
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0008152	metabolic process
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0016042	lipid catabolic process
GO:0032835	glomerulus development
GO:0035556	intracellular signal transduction
GO:0043087	regulation of GTPase activity
GO:0045859	regulation of protein kinase activity
GO:0046578	regulation of Ras protein signal transduction

Cellular Component

GO:0000139	Golgi membrane
GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:1921305

InterPro

IPR000008 C2 domain
IPR000159 Ras-association
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001192 Phosphoinositide phospholipase C family
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR001895 Guanine-nucleotide dissociation stimulator CDC25
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR023578 Ras guanine nucleotide exchange factor, domain
IPR029071 Ubiquitin-related domain

PFAM

PF00168
PF00788
PF00388
PF00387
PF00617
PF09279

PRINTS

PR00360
PR00390

PIRSF

SMART

SM00239
SM00314
SM00148
SM00149
SM00147

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt