InnateDB Protein
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IDBP-621355.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Fetub
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Protein Name
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fetuin beta
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Synonyms
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2310011O17Rik; AI255764; D17980; Gugu;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000128989
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InnateDB Gene
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IDBG-148802 (Fetub)
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Protein Structure
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Function |
Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening. {ECO:0000269PubMed:23562279}.
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Subcellular Localization |
Secreted {ECO:0000305PubMed:23562279}.
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Disease Associations |
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Tissue Specificity |
Liver, lung and tongue.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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|
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Molecular Function |
Accession |
GO Term |
GO:0004869
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cysteine-type endopeptidase inhibitor activity
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GO:0008191
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metalloendopeptidase inhibitor activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1890221
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InterPro |
IPR000010
Proteinase inhibitor I25, cystatin
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PFAM |
PF00031
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PRINTS |
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PIRSF |
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SMART |
SM00043
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TIGRFAMs |
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Modification |
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SwissProt |
Q9QXC1
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q6YJU2
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UniProt Splice Variant |
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Entrez Gene |
59083
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UniGene |
Mm.28461
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RefSeq |
NP_001077374
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MGI ID |
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MGI Symbol |
Fetub
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OMIM |
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CCDS |
CCDS37300
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HPRD |
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IMGT |
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EMBL |
AJ242927
AY138459
AY138460
BC018341
CT027991
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GenPept |
AAH18341
AAN34519
AAN34520
CAB62541
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