Version 5.4
Mus musculus Protein: Fetub
Summary
InnateDB Protein IDBP-621356.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fetub
Protein Name fetuin beta
Synonyms 2310011O17Rik; AI255764; D17980; Gugu;
Species Mus musculus
Ensembl Protein ENSMUSP00000128745
InnateDB Gene IDBG-148802 (Fetub)
Protein Structure
UniProt Annotation
Function Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening. {ECO:0000269PubMed:23562279}.
Subcellular Localization Secreted {ECO:0000305PubMed:23562279}.
Disease Associations
Tissue Specificity Liver, lung and tongue.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0008191 metalloendopeptidase inhibitor activity
Biological Process
GO:0007338 single fertilization
GO:0007339 binding of sperm to zona pellucida
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID MGI:1890221
InterPro IPR000010 Proteinase inhibitor I25, cystatin
PFAM PF00031
PRINTS
PIRSF
SMART SM00043
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QXC1
PhosphoSite PhosphoSite-
TrEMBL Q6YJU2
UniProt Splice Variant
Entrez Gene 59083
UniGene Mm.28461
RefSeq
MGI ID
MGI Symbol Fetub
OMIM
CCDS CCDS37300
HPRD
IMGT
EMBL AJ242927 AY138459 AY138460 BC018341 CT027991
GenPept AAH18341 AAN34519 AAN34520 CAB62541

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca