InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sh3glb1

Summary

InnateDB Protein

IDBP-621413.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sh3glb1

Protein Name

SH3-domain GRB2-like B1 (endophilin)

Synonyms

AA409932; AI314629; AU015566; Bif-1; mKIAA0491;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000129800

InnateDB Gene

IDBG-197628 (Sh3glb1)

Protein Structure

UniProt Annotation

Function

May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. {ECO:0000269PubMed:17086176}.

Subcellular Localization

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Mitochondrion outer membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Association with the Golgi apparatus depends on the cell type.

Disease Associations

Tissue Specificity

Isoform 1 is widely expressed. Isoform 2 is brain specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005504	fatty acid binding
GO:0005515	protein binding
GO:0042171	lysophosphatidic acid acyltransferase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0006654	phosphatidic acid biosynthetic process
GO:0006915	apoptotic process
GO:0008654	phospholipid biosynthetic process
GO:0032461	positive regulation of protein oligomerization
GO:0051084	'de novo' posttranslational protein folding
GO:0051259	protein oligomerization
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005740	mitochondrial envelope
GO:0005741	mitochondrial outer membrane
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0016020	membrane
GO:0043234	protein complex