InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tdrkh

Summary

InnateDB Protein

IDBP-621519.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tdrkh

Protein Name

tudor and KH domain containing protein

Synonyms

2700091C21Rik; Tdrd2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000129635

InnateDB Gene

IDBG-170105 (Tdrkh)

Protein Structure

UniProt Annotation

Function

Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules. {ECO:0000269PubMed:23714778}.

Subcellular Localization

Cytoplasm. Mitochondrion. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell- specific organelle required to repress transposon activity during meiosis. Colocalizes with pi- and piP-bodies, a subset of the nuage which contains secondary piRNAs. Associated with mitochondria in the germline.

Disease Associations

Tissue Specificity

Highly expressed in testis, present at lower level in brain. Weakly or not expreseed in other tissues (at protein level). {ECO:0000269PubMed:19918066}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding

Biological Process

GO:0007140	male meiosis
GO:0007283	spermatogenesis
GO:0009566	fertilization
GO:0030154	cell differentiation
GO:0031047	gene silencing by RNA
GO:0034587	piRNA metabolic process
GO:0043046	DNA methylation involved in gamete generation