InnateDB Protein
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IDBP-621588.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Zfyve27
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Protein Name
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zinc finger, FYVE domain containing 27
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000130684
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InnateDB Gene
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IDBG-167290 (Zfyve27)
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Protein Structure
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Function |
Functions as an upstream inhibitor of RAB11, regulating directional protein transport to the forming neurites. Involved in nerve growth factor-induced neurite formation. May have a more general role in cell projections formation (By similarity). {ECO:0000250}.
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Subcellular Localization |
Recycling endosome membrane {ECO:0000305PubMed:17082457}; Multi-pass membrane protein {ECO:0000305PubMed:17082457}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, growth cone membrane {ECO:0000269PubMed:17082457}; Multi-pass membrane protein {ECO:0000269PubMed:17082457}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localizes at both dendrites and axons.
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Disease Associations |
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Tissue Specificity |
Most abundant in cerebrum and cerebellum. Also detected in heart, thymus, spleen, intestine and lung. {ECO:0000269PubMed:17082457}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1919602
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InterPro |
IPR000306
FYVE zinc finger
IPR011011
Zinc finger, FYVE/PHD-type
IPR017455
Zinc finger, FYVE-related
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PFAM |
PF01363
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PRINTS |
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PIRSF |
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SMART |
SM00064
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TIGRFAMs |
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Modification |
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SwissProt |
Q3TXX3
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PhosphoSite |
PhosphoSite-Q3TXX3
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TrEMBL |
E9Q4U6
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UniProt Splice Variant |
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Entrez Gene |
319740
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UniGene |
Mm.490064
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RefSeq |
NP_796293
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MGI ID |
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MGI Symbol |
Zfyve27
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OMIM |
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CCDS |
CCDS29825
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HPRD |
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IMGT |
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EMBL |
AK159065
AL603804
BC042595
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GenPept |
AAH42595
BAE34791
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