InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zfp110

Summary

InnateDB Protein

IDBP-621672.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zfp110

Protein Name

zinc finger protein 110

Synonyms

2900024E01Rik; N28112; NRIF; Nrif1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000132060

InnateDB Gene

IDBG-143624 (Zfp110)

Protein Structure

UniProt Annotation

Function

Transcription regulator involved in NGFR/p75(NTR)- mediated apoptosis. Essential component of the NGFR/p75(NTR) apoptotic pathway: upon ligand-binding and subsequent cleavage of NGFR/p75(NTR), binds to the intracellular domain (ICD) cleavage product of NGFR/p75(NTR), translocates to the nucleus and induces apoptosis, possibly by regulating expression of key regulators of apoptosis. Induces NGFR/p75(NTR)-mediated apoptosis in retina and sympathetic neurons. May also regulate expression of neuronal cholesterol biosynthesis genes. Probably acts as a transcription repressor: specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. {ECO:0000269PubMed:10545116, ECO:0000269PubMed:15668238, ECO:0000269PubMed:16630834, ECO:0000269PubMed:18677445, ECO:0000269PubMed:18815271}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Translocates into the nucleus following binding to TRAF6 and subsequent ubiquitination at Lys-15.

Disease Associations

Tissue Specificity

Ubiquitously expressed at low level. Expressed at higher level in testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003676	nucleic acid binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005166	neurotrophin p75 receptor binding
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0046328	regulation of JNK cascade
GO:0051402	neuron apoptotic process
GO:0097191	extrinsic apoptotic signaling pathway
GO:1990009	retinal cell apoptotic process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:1890378

InterPro

IPR001909 Krueppel-associated box
IPR003309 Transcription regulator SCAN
IPR007087 Zinc finger, C2H2
IPR008916 Retrovirus capsid, C-terminal
IPR015880 Zinc finger, C2H2-like

PFAM

PF01352
PF02023
PF00096

PRINTS

PIRSF

SMART

SM00349
SM00431
SM00355

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q923B3