Version 5.4
Mus musculus Protein: Hsf3
Summary
InnateDB Protein IDBP-621688.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hsf3
Protein Name heat shock transcription factor 3
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000132248
InnateDB Gene IDBG-160961 (Hsf3)
Protein Structure
UniProt Annotation
Function DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription of non- classical heat-shock genes such as PDZD2 and PROM2. Protects cells against heat shock and proteotoxic stress. {ECO:0000269PubMed:19864465}.
Subcellular Localization Isoform 1: Cytoplasm {ECO:0000269PubMed:19864465}. Nucleus {ECO:0000269PubMed:19864465}. Note=Cytoplasmic under normal conditions. Translocates to the nucleus in response to heat shock. {ECO:0000269PubMed:19864465}.Isoform 2: Cytoplasm {ECO:0000269PubMed:19864465}. Note=Does not translocate to the nucleus in response to heat shock. {ECO:0000269PubMed:19864465}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0031490 chromatin DNA binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0034605 cellular response to heat
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:3045337
InterPro IPR000232 Heat shock factor (HSF)-type, DNA-binding
PFAM PF00447
PRINTS PR00056
PIRSF
SMART SM00415
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt D0VYS2
PhosphoSite PhosphoSite-D0VYS2
TrEMBL Q8BL67
UniProt Splice Variant
Entrez Gene 245525
UniGene Mm.166749
RefSeq
MGI ID
MGI Symbol Hsf3
OMIM
CCDS
HPRD
IMGT
EMBL AB510446 AB510447 AK046229 AL732365 AL831708 AL929273 BC117805
GenPept AAI17806 BAC32646 BAI50338 BAI50339

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca