InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rnf6

Summary

InnateDB Protein

IDBP-621715.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rnf6

Protein Name

ring finger protein (C3H2C3 type) 6

Synonyms

1200013I08Rik; 5730419H05Rik; AA537053;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000128774

InnateDB Gene

IDBG-208802 (Rnf6)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator. {ECO:0000269PubMed:11971979, ECO:0000269PubMed:16204183}.

Subcellular Localization

Nucleus. Cytoplasm. Cell projection, axon. Nucleus, PML body. Note=Localizes to the PML nuclear bodies in Sertoli cells.

Disease Associations

Tissue Specificity

Widely expressed with higher expression in the testis in both germ cells and Sertoli cells. {ECO:0000269PubMed:11971979}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding
GO:0050681	androgen receptor binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0030517	negative regulation of axon extension
GO:0044314	protein K27-linked ubiquitination
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060765	regulation of androgen receptor signaling pathway
GO:0070936	protein K48-linked ubiquitination
GO:0085020	protein K6-linked ubiquitination