InnateDB Protein
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IDBP-621751.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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D0H4S114
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Protein Name
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DNA segment, human D4S114
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Synonyms
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AI325076; D0H4S114; Harp; P311; PTZ17; SEZ17;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000130297
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InnateDB Gene
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IDBG-134320 (D0H4S114)
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Protein Structure
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Function |
May have roles in cellular differentiation. Ectopic expression induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis. May also have neural functions. Promotes axonal regeneration and augments motility of gliomas. Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3. May play a role in the regulation of alveolar generation. {ECO:0000269PubMed:12417574, ECO:0000269PubMed:14985127, ECO:0000269PubMed:16934802, ECO:0000269PubMed:18664493}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in brain and fetal lung. {ECO:0000269PubMed:16484684, ECO:0000269PubMed:8261136}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
GO:0017015
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regulation of transforming growth factor beta receptor signaling pathway
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GO:0031103
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axon regeneration
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GO:0045664
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regulation of neuron differentiation
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Cellular Component |
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PDB ID |
MGI:99444
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InterPro |
IPR024417
Neuronal protein 3.1
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PFAM |
PF11092
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q07475
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q542Q5
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UniProt Splice Variant |
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Entrez Gene |
27528
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UniGene |
Mm.471084
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RefSeq |
NP_001103458
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MGI ID |
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MGI Symbol |
Nrep
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OMIM |
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CCDS |
CCDS37756
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HPRD |
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IMGT |
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EMBL |
AK020629
AK081502
AK133769
BC054762
CH466557
EU447302
X70398
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GenPept |
AAH54762
ACC65771
BAB32157
BAC38238
BAE21830
CAA49848
EDK97072
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