Version 5.4
Mus musculus Protein: Slc5a11
Summary
InnateDB Protein IDBP-621788.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc5a11
Protein Name solute carrier family 5 (sodium/glucose cotransporter), member 11
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000127977
InnateDB Gene IDBG-209090 (Slc5a11)
Protein Structure
UniProt Annotation
Function Involved in the sodium-dependent cotransport of myo- inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D- xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000250UniProtKB:Q28728}; Multi-pass membrane protein {ECO:0000250UniProtKB:Q28728}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0015293 symporter activity
Biological Process
GO:0006810 transport
GO:0006814 sodium ion transport
GO:0006915 apoptotic process
GO:0008643 carbohydrate transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1919316
InterPro IPR001734 Sodium/solute symporter
IPR019900 Sodium/solute symporter, subgroup
PFAM PF00474
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K0E3
PhosphoSite PhosphoSite-
TrEMBL D3Z300
UniProt Splice Variant
Entrez Gene 233836
UniGene Mm.211838
RefSeq XP_006507775
MGI ID
MGI Symbol Slc5a11
OMIM
CCDS CCDS21819
HPRD
IMGT
EMBL AC138364 AF518726 BC031742
GenPept AAH31742 AAQ08402

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca