InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tlx1

Summary

InnateDB Protein

IDBP-621815.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tlx1

Protein Name

T-cell leukemia, homeobox 1

Synonyms

Hox-11; Hox11;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000133627

InnateDB Gene

IDBG-170668 (Tlx1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0007417	central nervous system development
GO:0008284	positive regulation of cell proliferation
GO:0030182	neuron differentiation
GO:0045165	cell fate commitment
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048535	lymph node development
GO:0048536	spleen development
GO:0048645	organ formation

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:98769

InterPro

IPR001356 Homeobox domain
IPR009057 Homeodomain-like

PFAM

PF00046

PRINTS

PIRSF

SMART

SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

G3UXB9

UniProt Splice Variant

Entrez Gene

21908

UniGene

Mm.391203

RefSeq

MGI ID

MGI Symbol

Tlx1

OMIM

CCDS

HPRD

IMGT

EMBL

AC170878

GenPept