Version 5.4
Mus musculus Protein: Mchr1
Summary
InnateDB Protein IDBP-621820.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mchr1
Protein Name melanin-concentrating hormone receptor 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000126191
InnateDB Gene IDBG-164553 (Mchr1)
Protein Structure
UniProt Annotation
Function Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0008022 protein C-terminus binding
GO:0030273 melanin-concentrating hormone receptor activity
GO:0042562 hormone binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007218 neuropeptide signaling pathway
GO:0051928 positive regulation of calcium ion transport
GO:0060259 regulation of feeding behavior
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0031513 nonmotile primary cilium
Protein Structure and Domains
PDB ID MGI:2180756
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR004047 Melanin-concentrating hormone 1 receptor
IPR008361 Melanin-concentrating hormone receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
PFAM PF00001
PF10320
PRINTS PR00237
PR01507
PR01783
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8JZL2
PhosphoSite PhosphoSite-Q8JZL2
TrEMBL Q3UY93
UniProt Splice Variant
Entrez Gene 207911
UniGene Mm.323523
RefSeq NP_660114
MGI ID
MGI Symbol Mchr1
OMIM
CCDS CCDS49675
HPRD
IMGT
EMBL AC102334 AF498247 AF498248 AK134867 AY049011 BC128286 BY276741 CAAA01177985
GenPept AAI28287 AAL06069 AAM22964 AAM22965 BAE22319

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca