InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kif20a

Summary

InnateDB Protein

IDBP-621821.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kif20a

Protein Name

kinesin family member 20A

Synonyms

AA415432; Rab6kifl;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000130045

InnateDB Gene

IDBG-135471 (Kif20a)

Protein Structure

UniProt Annotation

Function

Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle (By similarity). Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000250, ECO:0000269PubMed:9438855}.

Subcellular Localization

Golgi apparatus {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000305PubMed:9438855}.

Disease Associations

Tissue Specificity

Ubiquitously expressed, with highest levels in spleen and testis. {ECO:0000269PubMed:9438855}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0019901	protein kinase binding

Biological Process

GO:0000910	cytokinesis
GO:0001578	microtubule bundle formation
GO:0007018	microtubule-based movement
GO:0008152	metabolic process
GO:0015031	protein transport

Cellular Component

GO:0005794	Golgi apparatus
GO:0005819	spindle
GO:0005871	kinesin complex
GO:0005874	microtubule

Protein Structure and Domains

PDB ID

MGI:1201682

InterPro

IPR001752 Kinesin, motor domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00225

PRINTS

PR00380

PIRSF

SMART

SM00129

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P97329

PhosphoSite

PhosphoSite-P97329

TrEMBL

UniProt Splice Variant

Entrez Gene

19348

UniGene

Mm.413019

RefSeq

NP_001159879

MGI ID

MGI Symbol

Kif20a

OMIM

CCDS

CCDS29131

HPRD

IMGT

EMBL

AK083412 AK084732 AK144844 BC060608 Y09632

GenPept

AAH60608 BAC38906 BAC39267 BAE26095 CAA70845