InnateDB Protein
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IDBP-621823.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Kif20a
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Protein Name
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kinesin family member 20A
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Synonyms
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AA415432; Rab6kifl;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000132659
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InnateDB Gene
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IDBG-135471 (Kif20a)
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Protein Structure
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Function |
Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle (By similarity). Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000250, ECO:0000269PubMed:9438855}.
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Subcellular Localization |
Golgi apparatus {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000305PubMed:9438855}.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed, with highest levels in spleen and testis. {ECO:0000269PubMed:9438855}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
10 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1201682
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InterPro |
IPR001752
Kinesin, motor domain
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF00225
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PRINTS |
PR00380
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PIRSF |
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SMART |
SM00129
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TIGRFAMs |
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Modification |
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SwissProt |
P97329
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PhosphoSite |
PhosphoSite-P97329
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
19348
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UniGene |
Mm.413019
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RefSeq |
NP_033030
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MGI ID |
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MGI Symbol |
Kif20a
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OMIM |
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CCDS |
CCDS29131
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HPRD |
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IMGT |
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EMBL |
AK083412
AK084732
AK144844
BC060608
Y09632
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GenPept |
AAH60608
BAC38906
BAC39267
BAE26095
CAA70845
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