InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rev3l

Summary

InnateDB Protein

IDBP-621889.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rev3l

Protein Name

REV3-like, catalytic subunit of DNA polymerase zeta RAD54 like (S. cerevisiae)

Synonyms

Rev; Rev3; Sez4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000131519

InnateDB Gene

IDBG-144818 (Rev3l)

Protein Structure

UniProt Annotation

Function

Interacts with MAD2L2 to form the error prone DNA polymerase zeta involved in translesion DNA synthesis. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0046872	metal ion binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006260	DNA replication
GO:0006261	DNA-dependent DNA replication
GO:0006281	DNA repair
GO:0019985	translesion synthesis

Cellular Component

GO:0005634	nucleus
GO:0005694	chromosome
GO:0016035	zeta DNA polymerase complex

Protein Structure and Domains

PDB ID

MGI:1337131

InterPro

IPR006133 DNA-directed DNA polymerase, family B, exonuclease domain
IPR006134 DNA-directed DNA polymerase, family B, multifunctional domain
IPR006172 DNA-directed DNA polymerase, family B
IPR012337 Ribonuclease H-like domain

PFAM

PF03104
PF00136

PRINTS

PR00106

PIRSF

SMART

SM00486

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt