InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rabggtb

Summary

InnateDB Protein

IDBP-621966.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rabggtb

Protein Name

RAB geranylgeranyl transferase, b subunit

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000129481

InnateDB Gene

IDBG-200615 (Rabggtb)

Protein Structure

UniProt Annotation

Function

Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. {ECO:0000269PubMed:21520375}.

Subcellular Localization

Disease Associations

Tissue Specificity

Ubiquitous. Detected in all the major organs in adult animals. {ECO:0000269PubMed:9031634}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004663	Rab geranylgeranyltransferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0017137	Rab GTPase binding