Version 5.4
Mus musculus Protein: Aph1c
Summary
InnateDB Protein IDBP-622000.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aph1c
Protein Name anterior pharynx defective 1c homolog (C. elegans)
Synonyms 0610008A10Rik; APH-1b; Aph1b;
Species Mus musculus
Ensembl Protein ENSMUSP00000130359
InnateDB Gene IDBG-180033 (Aph1c)
Protein Structure
UniProt Annotation
Function Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0008233 peptidase activity
Biological Process
GO:0001656 metanephros development
GO:0006508 proteolysis
GO:0007219 Notch signaling pathway
GO:0016485 protein processing
GO:0043085 positive regulation of catalytic activity
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1915568
InterPro IPR009294 Gamma-secretase subunit Aph-1
PFAM PF06105
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9DCZ9
PhosphoSite PhosphoSite-Q9DCZ9
TrEMBL Q4R1J7
UniProt Splice Variant
Entrez Gene 68318
UniGene Mm.284229
RefSeq NP_080950
MGI ID
MGI Symbol Aph1c
OMIM
CCDS CCDS23308
HPRD
IMGT
EMBL AB197123 AC142504 AK002310 AK155147 BC050923 BC063254
GenPept AAH50923 AAH63254 BAB22004 BAE02661 BAE33077

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca