InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slco1a4

Summary

InnateDB Protein

IDBP-622011.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slco1a4

Protein Name

solute carrier organic anion transporter family, member 1a4

Synonyms

AI785519; Oatp1a4; Oatp2; Slc21a5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000130746

InnateDB Gene

IDBG-196555 (Slco1a4)

Protein Structure

UniProt Annotation

Function

Mediates the Na(+)-independent transport of organic anions such as taurocholate, cholate, 17-beta-glucuronosyl estradiol, estrone-3-sulfate, the cardiac glycosides ouabain and digoxin and thyroid hormones. {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Highly expressed in brain and liver. Detected at very low levels in heart and lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0008514	organic anion transmembrane transporter activity
GO:0015125	bile acid transmembrane transporter activity

Biological Process

GO:0006810	transport
GO:0006820	anion transport
GO:0015721	bile acid and bile salt transport
GO:0043252	sodium-independent organic anion transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1351896

InterPro

IPR002350 Kazal domain
IPR004156 Organic anion transporter polypeptide OATP
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF00050
PF07648
PF03137
PF07690

PRINTS

PIRSF

SMART

SM00280

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9EP96