InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cyb5r4

Summary

InnateDB Protein

IDBP-622033.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyb5r4

Protein Name

cytochrome b5 reductase 4

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000126119

InnateDB Gene

IDBG-189823 (Cyb5r4)

Protein Structure

UniProt Annotation

Function

NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). {ECO:0000269PubMed:15247412}.

Subcellular Localization

Endoplasmic reticulum. Note=Soluble protein. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Isoform 2 is expressed in testis, brain, skeletal muscle and in the male germline. {ECO:0000269PubMed:14962668, ECO:0000269PubMed:16814408}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003958	NADPH-hemoprotein reductase activity
GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H
GO:0005515	protein binding
GO:0016174	NAD(P)H oxidase activity
GO:0016491	oxidoreductase activity
GO:0016653	oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor
GO:0020037	heme binding
GO:0046872	metal ion binding
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0006091	generation of precursor metabolites and energy
GO:0006739	NADP metabolic process
GO:0006801	superoxide metabolic process
GO:0030073	insulin secretion
GO:0042168	heme metabolic process
GO:0042593	glucose homeostasis
GO:0046677	response to antibiotic
GO:0048468	cell development
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:2386848

InterPro

IPR001199 Cytochrome b5-like heme/steroid binding domain
IPR001433 Oxidoreductase FAD/NAD(P)-binding
IPR001834 NADH:cytochrome b5 reductase (CBR)
IPR007052 CS domain
IPR008333 Oxidoreductase, FAD-binding domain
IPR008978 HSP20-like chaperone
IPR017938 Riboflavin synthase-like beta-barrel

PFAM

PF00173
PF00175
PF04969
PF00970

PRINTS

PR00363
PR00406

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3TDX8