InnateDB Protein
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IDBP-62251.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PIP4K2A
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Protein Name
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phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
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Synonyms
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PI5P4KA; PIP5K2A; PIP5KII-alpha; PIP5KIIA; PIPK;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000365757
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InnateDB Gene
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IDBG-62249 (PIP4K2A)
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Protein Structure
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Function |
Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin- stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size. {ECO:0000269PubMed:18364242}.
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Subcellular Localization |
Cell membrane {ECO:0000250}. Nucleus {ECO:0000269PubMed:20583997}. Cytoplasm {ECO:0000269PubMed:20583997}. Note=May translocate from the cytosol to the cell membrane upon activation of tyrosine phosphorylation. May translocate from the inner to the outer segments of the rod photoreceptor cells in response to light (By similarity). Localization to the nucleus is modulated by the interaction with PIP4K2B. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed ubiquitously, with high levels in the brain. Present in most tissues, except notably skeletal muscle and small intestine. {ECO:0000269PubMed:7639683, ECO:0000269PubMed:7852364}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005524
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ATP binding
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GO:0016307
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phosphatidylinositol phosphate kinase activity
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GO:0016308
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1-phosphatidylinositol-4-phosphate 5-kinase activity
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GO:0016309
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1-phosphatidylinositol-5-phosphate 4-kinase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002498
Phosphatidylinositol-4-phosphate 5-kinase, core
IPR016034
Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup
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PFAM |
PF01504
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PRINTS |
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PIRSF |
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SMART |
SM00330
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TIGRFAMs |
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Modification |
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SwissProt |
P48426
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PhosphoSite |
PhosphoSite-P48426
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TrEMBL |
S4R320
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UniProt Splice Variant |
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Entrez Gene |
5305
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UniGene |
Hs.644929
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RefSeq |
NP_005019
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HUGO |
HGNC:8997
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OMIM |
603140
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CCDS |
CCDS7141
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HPRD |
11931
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IMGT |
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EMBL |
AK294817
AL157707
AL390318
AL513128
BC018034
CH471072
EF445009
S78798
U14957
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GenPept |
AAA64835
AAB35041
AAH18034
ACA06044
ACA06045
BAG57933
CAH70526
CAH72211
CAI39585
EAW86140
EAW86141
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