InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eif2s2

Summary

InnateDB Protein

IDBP-622557.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eif2s2

Protein Name

eukaryotic translation initiation factor 2, subunit 2 (beta)

Synonyms

2810026E11Rik; 38kDa; AA408636; AA571381; AA986487; AW822225; D2Ertd303e; EIF2; EIF2B;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000128257

InnateDB Gene

IDBG-210491 (Eif2s2)

Protein Structure

UniProt Annotation

Function

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003743	translation initiation factor activity
GO:0046872	metal ion binding

Biological Process

GO:0001701	in utero embryonic development
GO:0002176	male germ cell proliferation
GO:0006413	translational initiation
GO:0008584	male gonad development

Cellular Component

GO:0005575

cellular_component

Protein Structure and Domains

PDB ID

MGI:1914454

InterPro

IPR002735 Translation initiation factor IF2/IF5
IPR016189 Translation initiation factor IF2/IF5, N-terminal
IPR016190 Translation initiation factor IF2/IF5, zinc-binding

PFAM

PF01873

PRINTS

PIRSF

SMART

SM00653

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99L45