Version 5.4
Mus musculus Protein: Dmbx1
Summary
InnateDB Protein IDBP-622623.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dmbx1
Protein Name diencephalon/mesencephalon homeobox 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000134457
InnateDB Gene IDBG-176985 (Dmbx1)
Protein Structure
UniProt Annotation
Function Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5'-TAATCCGATTA-3') sequence. Required for brain development, neonatal survival, postnatal growth, and nursing ability. {ECO:0000269PubMed:11914943, ECO:0000269PubMed:12055180, ECO:0000269PubMed:15314164, ECO:0000269PubMed:15890343}.
Subcellular Localization Nucleus {ECO:0000250UniProtKB:O35137, ECO:0000255PROSITE-ProRule:PRU00108, ECO:0000255PROSITE- ProRule:PRU00138}.
Disease Associations
Tissue Specificity Expressed in adult brain, stomach, and testis. Expressed in the developing diencephalon, midbrain and hindbrain. During limb development, expressed in a temporal pattern with expression being first restricted to the forelimbs and then subsequently to the hindlimbs. {ECO:0000269PubMed:11744391, ECO:0000269PubMed:11914943, ECO:0000269PubMed:12111214, ECO:0000269PubMed:12175514}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007417 central nervous system development
GO:0007420 brain development
GO:0008343 adult feeding behavior
GO:0008344 adult locomotory behavior
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048589 developmental growth
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Protein Structure and Domains
PDB ID MGI:2153518
InterPro IPR001356 Homeobox domain
IPR003654 OAR domain
IPR009057 Homeodomain-like
PFAM PF00046
PF03826
PRINTS
PIRSF
SMART SM00389
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91ZK4
PhosphoSite PhosphoSite-Q91ZK4
TrEMBL
UniProt Splice Variant
Entrez Gene 140477
UniGene Mm.413175
RefSeq
MGI ID
MGI Symbol Dmbx1
OMIM
CCDS CCDS18500
HPRD
IMGT
EMBL AB037698 AF421857 AF421858 AF448118 AF461039 AF463513 AF499446 AL627105 BC050912
GenPept AAH50912 AAL30508 AAL30509 AAL66343 AAL68836 AAM78514 AAN76724 BAC00919 CAM22665

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca