InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bcar1

Summary

InnateDB Protein

IDBP-622802.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bcar1

Protein Name

breast cancer anti-estrogen resistance 1

Synonyms

AI385681; Cas; Crkas;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000129584

InnateDB Gene

IDBG-193577 (Bcar1)

Protein Structure

UniProt Annotation

Function

Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration (By similarity). Has been shown to be essential in cardiovascular development during embryogenesis. {ECO:0000250}.

Subcellular Localization

Cell junction, focal adhesion {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 66 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	66 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0019901	protein kinase binding

Biological Process

GO:0007015	actin filament organization
GO:0007155	cell adhesion
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007229	integrin-mediated signaling pathway
GO:0008286	insulin receptor signaling pathway
GO:0010595	positive regulation of endothelial cell migration
GO:0016477	cell migration
GO:0030335	positive regulation of cell migration
GO:0035729	cellular response to hepatocyte growth factor stimulus
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048012	hepatocyte growth factor receptor signaling pathway
GO:0050851	antigen receptor-mediated signaling pathway
GO:0050853	B cell receptor signaling pathway
GO:0060326	cell chemotaxis

Cellular Component

GO:0001726	ruffle
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0030027	lamellipodium

Protein Structure and Domains

PDB ID

MGI:108091

InterPro

IPR001452 SH3 domain
IPR011511 Variant SH3 domain
IPR013315 Spectrin alpha chain, SH3 domain
IPR014928 Serine rich protein interaction
IPR021901 CAS family, DUF3513

PFAM

PF00018
PF14604
PF07653
PF08824
PF12026

PRINTS

PR00452
PR01887

PIRSF

SMART

SM00326

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt