InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mut

Summary

InnateDB Protein

IDBP-622819.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mut

Protein Name

methylmalonyl-Coenzyme A mutase

Synonyms

D230010K02Rik; Mcm;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000130941

InnateDB Gene

IDBG-183529 (Mut)

Protein Structure

UniProt Annotation

Function

Involved in the degradation of several amino acids, odd- chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. {ECO:0000250}.

Subcellular Localization

Mitochondrion matrix.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004494	methylmalonyl-CoA mutase activity
GO:0016853	isomerase activity
GO:0016866	intramolecular transferase activity
GO:0031419	cobalamin binding
GO:0046872	metal ion binding
GO:0072341	modified amino acid binding

Biological Process

GO:0008152	metabolic process
GO:0009791	post-embryonic development
GO:0050667	homocysteine metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

MGI:97239

InterPro

IPR006098 Methylmalonyl-CoA mutase, alpha chain, catalytic
IPR006099 Methylmalonyl-CoA mutase, alpha/beta chain, catalytic
IPR006158 Cobalamin (vitamin B12)-binding domain
IPR006159 Methylmalonyl-CoA mutase, C-terminal
IPR016176 Cobalamin (vitamin B12)-dependent enzyme, catalytic

PFAM

PF01642
PF02310

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P16332

PhosphoSite