Version 5.4
Mus musculus Protein: Atf2
Summary
InnateDB Protein IDBP-622922.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Atf2
Protein Name activating transcription factor 2
Synonyms Atf-2; CRE-BP; Creb2; D130078H02Rik; D18875; mXBP; Tg(Gzma-Klra1)7Wum;
Species Mus musculus
Ensembl Protein ENSMUSP00000133632
InnateDB Gene IDBG-180520 (Atf2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 208 interaction(s) predicted by orthology.
Experimentally validated
Total 41 [view]
Protein-Protein 29 [view]
Protein-DNA 12 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 208 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0008140 cAMP response element binding protein binding
GO:0019901 protein kinase binding
GO:0035497 cAMP response element binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0003151 outflow tract morphogenesis
GO:0006355 regulation of transcription, DNA-templated
GO:0006970 response to osmotic stress
GO:0016573 histone acetylation
GO:0031573 intra-S DNA damage checkpoint
GO:0032915 positive regulation of transforming growth factor beta2 production
GO:0045444 fat cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060612 adipose tissue development
GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005741 mitochondrial outer membrane
GO:0016020 membrane
GO:0035861 site of double-strand break
Protein Structure and Domains
PDB ID MGI:109349
InterPro IPR004827 Basic-leucine zipper domain
IPR007087 Zinc finger, C2H2
PFAM PF00170
PF07716
PF00096
PRINTS
PIRSF
SMART SM00338
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q8CBR9
UniProt Splice Variant
Entrez Gene 11909
UniGene Mm.406406
RefSeq NP_001271300
MGI ID
MGI Symbol Atf2
OMIM
CCDS
HPRD
IMGT
EMBL AK035438 AL844581 AL845523
GenPept BAC29065

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca