Version 5.4
Mus musculus Protein: Tifab
Summary
InnateDB Protein IDBP-622939.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tifab
Protein Name TRAF-interacting protein with forkhead-associated domain, family member B
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000131162
InnateDB Gene IDBG-157110 (Tifab)
Protein Structure
UniProt Annotation
Function Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA. {ECO:0000269PubMed:15047173}.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed at high levels in spleen and at moderate levels in lung, thymus, and small intestine. {ECO:0000269PubMed:15047173}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
Protein Structure and Domains
PDB ID MGI:2385852
InterPro IPR000253 Forkhead-associated (FHA) domain
IPR008984 SMAD/FHA domain
PFAM PF00498
PRINTS
PIRSF
SMART SM00240
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8JZM6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 212937
UniGene Mm.116697
RefSeq NP_666088
MGI ID
MGI Symbol Tifab
OMIM
CCDS CCDS26558
HPRD
IMGT
EMBL AK036643 AK153654 AK170349 AK220206 BC005528 BC027057 BC031130
GenPept AAH05528 AAH27057 AAH31130 BAC29516 BAD90131 BAE32135 BAE41737

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca