Version 5.4
Mus musculus Protein: Degs2
Summary
InnateDB Protein IDBP-622943.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Degs2
Protein Name degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase
Synonyms 2210008A03Rik; AI852933; DES2;
Species Mus musculus
Ensembl Protein ENSMUSP00000125891
InnateDB Gene IDBG-170855 (Degs2)
Protein Structure
UniProt Annotation
Function Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-hydroxylase. {ECO:0000269PubMed:11937514, ECO:0000269PubMed:14731113, ECO:0000269PubMed:16571104}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:16571104, ECO:0000305}; Multi-pass membrane protein {ECO:0000269PubMed:16571104, ECO:0000305}.
Disease Associations
Tissue Specificity Highly expressed in intestinal crypt cells and adjacent epithelial cells (at protein level). {ECO:0000269PubMed:14731113}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000170 sphingosine hydroxylase activity
GO:0042284 sphingolipid delta-4 desaturase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006667 sphinganine metabolic process
GO:0030148 sphingolipid biosynthetic process
GO:0046513 ceramide biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1917309
InterPro IPR005804 Fatty acid desaturase, type 1
IPR013866 Sphingolipid delta4-desaturase, N-terminal
PFAM PF00487
PF08557
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R2F2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 70059
UniGene Mm.207605
RefSeq NP_001164473
MGI ID
MGI Symbol Degs2
OMIM
CCDS CCDS49170
HPRD
IMGT
EMBL AF466377 AK162979 BC016427
GenPept AAH16427 AAM12533 BAE37145

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca