Version 5.4
Mus musculus Protein: Dhtkd1
Summary
InnateDB Protein IDBP-623198.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dhtkd1
Protein Name dehydrogenase E1 and transketolase domain containing 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000129194
InnateDB Gene IDBG-134590 (Dhtkd1)
Protein Structure
UniProt Annotation
Function The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity
GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO:0030976 thiamine pyrophosphate binding
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006091 generation of precursor metabolites and energy
GO:0006096 glycolytic process
GO:0006099 tricarboxylic acid cycle
GO:0008152 metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID MGI:2445096
InterPro IPR001017 Dehydrogenase, E1 component
IPR005475 Transketolase-like, pyrimidine-binding domain
IPR011603 2-oxoglutarate dehydrogenase, E1 component
IPR029061 Thiamin diphosphate-binding fold
PFAM PF00676
PF02779
PRINTS
PIRSF PIRSF000157
SMART SM00861
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A2ATU0
PhosphoSite PhosphoSite-A2ATU0
TrEMBL
UniProt Splice Variant
Entrez Gene 209692
UniGene Mm.403087
RefSeq NP_001074600
MGI ID
MGI Symbol Dhtkd1
OMIM
CCDS CCDS38040
HPRD
IMGT
EMBL AK050057 AK173223 AL928924 BC117994
GenPept AAI17995 BAC34055 BAD32501 CAM20352

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca