Version 5.4
Homo sapiens Protein: C3orf33
Summary
InnateDB Protein IDBP-62331.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C3orf33
Protein Name chromosome 3 open reading frame 33
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000342512
InnateDB Gene IDBG-62329 (C3orf33)
Protein Structure
UniProt Annotation
Function Isoform 2: Secreted protein may play a role in transcription regulation via the MAPK3/MAPK1 pathway through an unidentified receptor on the plasma membrane.
Subcellular Localization Isoform 1: Membrane {ECO:0000305}; Single- pass membrane protein {ECO:0000305}.Isoform 2: Secreted {ECO:0000269PubMed:20680465}.
Disease Associations
Tissue Specificity Highly expressed in ileocecal tissue and endometrium. {ECO:0000269PubMed:20680465}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0016788 hydrolase activity, acting on ester bonds
Biological Process
GO:0008152 metabolic process
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0070373 negative regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005615 extracellular space
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR016071 Staphylococcal nuclease (SNase-like), OB-fold
PFAM PF00565
PRINTS
PIRSF
SMART SM00318
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6P1S2
PhosphoSite PhosphoSite-Q6P1S2
TrEMBL
UniProt Splice Variant
Entrez Gene 285315
UniGene Hs.350846
RefSeq XP_005247435
HUGO HGNC:26434
OMIM
CCDS
HPRD 08095
IMGT
EMBL AC104472 AF115515 AK055701 AK289890 BC042198 BC064898 CH471052
GenPept AAH42198 AAH64898 AAO06952 BAB70989 BAF82579 EAW78746

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca