InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VPS33A

Summary

InnateDB Protein

IDBP-62334.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VPS33A

Protein Name

vacuolar protein sorting 33 homolog A (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000267199

InnateDB Gene

IDBG-62332 (VPS33A)

Protein Structure

UniProt Annotation

Function

May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. {ECO:0000250}.

Subcellular Localization

Late endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Lysosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006904	vesicle docking involved in exocytosis
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0030220	platelet formation
GO:0032400	melanosome localization
GO:0032418	lysosome localization
GO:0048070	regulation of developmental pigmentation

Cellular Component

GO:0005765	lysosomal membrane
GO:0005769	early endosome
GO:0005770	late endosome
GO:0030897	HOPS complex
GO:0031902	late endosome membrane
GO:0048471	perinuclear region of cytoplasm