Version 5.4
Mus musculus Protein: Vdr
Summary
InnateDB Protein IDBP-623345.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Vdr
Protein Name vitamin D receptor
Synonyms Nr1i1;
Species Mus musculus
Ensembl Protein ENSMUSP00000134584
InnateDB Gene IDBG-179227 (Vdr)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 101 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 15 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 101 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0008270 zinc ion binding
GO:0038186 lithocholic acid receptor activity
GO:0043565 sequence-specific DNA binding
GO:0046965 retinoid X receptor binding
GO:0070644 vitamin D response element binding
GO:1902098 calcitriol binding
GO:1902121 lithocholic acid binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000902 cell morphogenesis
GO:0001501 skeletal system development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0007275 multicellular organismal development
GO:0007595 lactation
GO:0009887 organ morphogenesis
GO:0010839 negative regulation of keratinocyte proliferation
GO:0010980 positive regulation of vitamin D 24-hydroxylase activity
GO:0038183 bile acid signaling pathway
GO:0045618 positive regulation of keratinocyte differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046697 decidualization
GO:0050892 intestinal absorption
GO:0060058 positive regulation of apoptotic process involved in mammary gland involution
GO:0060745 mammary gland branching involved in pregnancy
GO:0070561 vitamin D receptor signaling pathway
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:103076
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
PFAM PF00105
PRINTS PR00047
PIRSF
SMART SM00399
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL G3UZP9
UniProt Splice Variant
Entrez Gene 22337
UniGene Mm.453871
RefSeq
MGI ID
MGI Symbol Vdr
OMIM
CCDS
HPRD
IMGT
EMBL AC158787
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca