InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Banp

Summary

InnateDB Protein

IDBP-623419.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Banp

Protein Name

BTG3 associated nuclear protein

Synonyms

AA408158; SMAR1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000132095

InnateDB Gene

IDBG-196950 (Banp)

Protein Structure

UniProt Annotation

Function

Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest and inhibits tumor growth. {ECO:0000269PubMed:10950932, ECO:0000269PubMed:12494467, ECO:0000269PubMed:15371550, ECO:0000269PubMed:15623522, ECO:0000269PubMed:15701641, ECO:0000269PubMed:16166625, ECO:0000269PubMed:17229733}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:10940556, ECO:0000269PubMed:12494467, ECO:0000269PubMed:15371550, ECO:0000269PubMed:15701641, ECO:0000269PubMed:16166625}.

Disease Associations

Tissue Specificity

Highly expressed in heart, spleen, and thymus. Isoform 1 is highly expressed in kidney, brain and testis. Isoform 3 is highly expressed in kidney and lung. {ECO:0000269PubMed:10940556, ECO:0000269PubMed:10950932, ECO:0000269PubMed:12494467}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0003677	DNA binding
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007049	cell cycle
GO:0007275	multicellular organismal development
GO:0016568	chromatin modification
GO:0034504	protein localization to nucleus
GO:0042177	negative regulation of protein catabolic process