Version 5.4
Mus musculus Protein: Rnf152
Summary
InnateDB Protein IDBP-623449.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rnf152
Protein Name ring finger protein 152
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000128632
InnateDB Gene IDBG-185171 (Rnf152)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed (By similarity). {ECO:0000250}.
Subcellular Localization Lysosome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006915 apoptotic process
GO:0070936 protein K48-linked ubiquitination
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2443787
InterPro IPR001841 Zinc finger, RING-type
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF13639
PF14634
PF00097
PRINTS
PIRSF
SMART SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BG47
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 320311
UniGene Mm.408249
RefSeq NP_001153840
MGI ID
MGI Symbol Rnf152
OMIM
CCDS CCDS15204
HPRD
IMGT
EMBL AK035832 AK044638 BC118961
GenPept AAI18962 BAC29205 BAC32015

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca