InnateDB Protein
|
IDBP-623482.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Tbx6
|
Protein Name
|
T-box 6
|
Synonyms
|
rv;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000126418
|
InnateDB Gene
|
IDBG-209827 (Tbx6)
|
Protein Structure
|
|
Function |
T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia. {ECO:0000269PubMed:15545628, ECO:0000269PubMed:18575602, ECO:0000269PubMed:21331042, ECO:0000269PubMed:9490412}.
|
Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00201}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
|
Protein-Protein |
4
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0001085
|
RNA polymerase II transcription factor binding
|
GO:0001102
|
RNA polymerase II activating transcription factor binding
|
GO:0001191
|
RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription
|
GO:0003677
|
DNA binding
|
GO:0003700
|
sequence-specific DNA binding transcription factor activity
|
|
Biological Process |
GO:0000122
|
negative regulation of transcription from RNA polymerase II promoter
|
GO:0001707
|
mesoderm formation
|
GO:0001708
|
cell fate specification
|
GO:0006351
|
transcription, DNA-templated
|
GO:0006355
|
regulation of transcription, DNA-templated
|
GO:0010977
|
negative regulation of neuron projection development
|
GO:0014043
|
negative regulation of neuron maturation
|
GO:0023019
|
signal transduction involved in regulation of gene expression
|
GO:0032525
|
somite rostral/caudal axis specification
|
GO:0045944
|
positive regulation of transcription from RNA polymerase II promoter
|
|
Cellular Component |
|
PDB ID |
MGI:102539
|
InterPro |
IPR001699
Transcription factor, T-box
IPR002070
Transcription factor, Brachyury
IPR008967
p53-like transcription factor, DNA-binding
|
PFAM |
PF00907
|
PRINTS |
PR00937
PR00938
|
PIRSF |
|
SMART |
SM00425
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P70327
|
PhosphoSite |
PhosphoSite-P70327
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
21389
|
UniGene |
Mm.727
|
RefSeq |
XP_006507616
|
MGI ID |
|
MGI Symbol |
Tbx6
|
OMIM |
|
CCDS |
|
HPRD |
|
IMGT |
|
EMBL |
AY654733
BC140951
U57331
|
GenPept |
AAC53110
AAI40952
AAT72924
|
|
|