Version 5.4
Mus musculus Protein: Trat1
Summary
InnateDB Protein IDBP-623661.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trat1
Protein Name T cell receptor associated transmembrane adaptor 1
Synonyms C030046M14Rik; Tcrim; Trim;
Species Mus musculus
Ensembl Protein ENSMUSP00000129808
InnateDB Gene IDBG-164471 (Trat1)
Protein Structure
UniProt Annotation
Function Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells. {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Present in T-cells (at protein level). {ECO:0000269PubMed:11439161}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0001920 negative regulation of receptor recycling
GO:0002376 immune system process
GO:0050850 positive regulation of calcium-mediated signaling
GO:0050862 positive regulation of T cell receptor signaling pathway
GO:0051051 negative regulation of transport
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0042101 T cell receptor complex
Protein Structure and Domains
PDB ID MGI:1924897
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3UU67
PhosphoSite PhosphoSite-Q3UU67
TrEMBL
UniProt Splice Variant
Entrez Gene 77647
UniGene Mm.167298
RefSeq NP_938039
MGI ID
MGI Symbol Trat1
OMIM
CCDS CCDS37352
HPRD
IMGT
EMBL AK138735 BC104350 BC104351
GenPept AAI04351 AAI04352 BAE23761

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca