Version 5.4
Mus musculus Protein: Sirt2
Summary
InnateDB Protein IDBP-623686.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sirt2
Protein Name sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae)
Synonyms 5730427M03Rik; Sir2l; SIR2L2;
Species Mus musculus
Ensembl Protein ENSMUSP00000132783
InnateDB Gene IDBG-164343 (Sirt2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 98 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 98 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0033558 protein deacetylase activity
GO:0048487 beta-tubulin binding
GO:0051287 NAD binding
GO:0070403 NAD+ binding
Biological Process
GO:0006476 protein deacetylation
GO:0016575 histone deacetylation
GO:0090042 tubulin deacetylation
GO:1901026 ripoptosome assembly involved in necroptotic process
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1927664
InterPro IPR003000 Sirtuin family
IPR017328 Sirtuin, class I
IPR026590 Sirtuin family, catalytic core domain
IPR029035 DHS-like NAD/FAD-binding domain
PFAM PF02146
PRINTS
PIRSF PIRSF037938
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E9PXF5
UniProt Splice Variant
Entrez Gene 64383
UniGene
RefSeq NP_001116238
MGI ID
MGI Symbol Sirt2
OMIM
CCDS CCDS52165
HPRD
IMGT
EMBL AC171210
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca