InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gprasp1

Summary

InnateDB Protein

IDBP-623691.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gprasp1

Protein Name

G protein-coupled receptor associated sorting protein 1

Synonyms

2210415K24Rik; 3110031O14Rik; C87852; GASP; GASP1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000132225

InnateDB Gene

IDBG-172647 (Gprasp1)

Protein Structure

UniProt Annotation

Function

Modulates lysosomal sorting and functional down- regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN1P1/BECN2. {ECO:0000269PubMed:23954414}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the brain, with higher expression in the hippocampus, hypothalamus and olfactory bulb. {ECO:0000269PubMed:15086532}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0008333	endosome to lysosome transport
GO:1990172	G-protein coupled receptor catabolic process

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:1917418

InterPro

IPR006911 Armadillo repeat-containing domain
IPR016024 Armadillo-type fold

PFAM

PF04826

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5U4C1

PhosphoSite

PhosphoSite-Q5U4C1

TrEMBL

UniProt Splice Variant

Entrez Gene

67298

UniGene

Mm.475515

RefSeq

MGI ID

MGI Symbol

Gprasp1

OMIM

CCDS

CCDS30409

HPRD

IMGT

EMBL

AB093241 AK039156 AK050919 AK083192 AL683822 BC027187 BC085157

GenPept

AAH27187 AAH85157 BAC30259 BAC34459 BAC38803 BAC41425 CAM27375