InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: H1fnt

Summary

InnateDB Protein

IDBP-623694.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

H1fnt

Protein Name

H1 histone family, member N, testis-specific

Synonyms

1700026P10Rik; H1t2; Hanp1; mH1t2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000127616

InnateDB Gene

IDBG-216062 (H1fnt)

Protein Structure

UniProt Annotation

Function

Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone- protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1. {ECO:0000269PubMed:15710904, ECO:0000269PubMed:16055721}.

Subcellular Localization

Nucleus. Chromosome. Note=In round and elongating spermatids, specifically localizes to a chromatin domain at the apical pole.

Disease Associations

Tissue Specificity

Testis-specific. Specifically expressed in haploid germ cells. {ECO:0000269PubMed:15710904, ECO:0000269PubMed:16055721}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005524	ATP binding

Biological Process

GO:0006997	nucleus organization
GO:0007275	multicellular organismal development
GO:0007290	spermatid nucleus elongation
GO:0030261	chromosome condensation
GO:0035092	sperm chromatin condensation