InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plcg1

Summary

InnateDB Protein

IDBP-623719.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plcg1

Protein Name

phospholipase C, gamma 1

Synonyms

AI894140; Cded; Plc-1; Plc-gamma1; Plcg-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000133771

InnateDB Gene

IDBG-211621 (Plcg1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 154 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	32 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	154 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0005168	neurotrophin TRKA receptor binding
GO:0005509	calcium ion binding
GO:0008081	phosphoric diester hydrolase activity
GO:0035254	glutamate receptor binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006629	lipid metabolic process
GO:0008152	metabolic process
GO:0035556	intracellular signal transduction
GO:0043536	positive regulation of blood vessel endothelial cell migration
GO:0045766	positive regulation of angiogenesis
GO:0050852	T cell receptor signaling pathway
GO:0071364	cellular response to epidermal growth factor stimulus

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0008180	COP9 signalosome
GO:0030027	lamellipodium

Protein Structure and Domains

PDB ID

MGI:97615

InterPro

IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001192 Phosphoinositide phospholipase C family
IPR001849 Pleckstrin homology domain
IPR002048 EF-hand domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

PFAM

PF00388
PF00169
PF00036
PF13202
PF13405
PF09279

PRINTS

PR00390

PIRSF

SMART

SM00148
SM00233
SM00054

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q792T1

UniProt Splice Variant

Entrez Gene

18803

UniGene

Mm.486517

RefSeq

MGI ID

MGI Symbol

Plcg1

OMIM

CCDS

HPRD

IMGT

EMBL

AH007341 AL590389

GenPept

AAD13798